Osteoarthritis is the most common form of arthritis and the leading cause of disability worldwide, mainly due to joint pain. Osteoarthritis affects about 4% of the population worldwide and its prevalence becomes more pronounced with age. In fact, clinical osteoarthritis is present in 14% and 34% of adults aged 25+ and 65+, respectively [1].

Cause

Arthritis is caused by the interaction of risk factors such as age, gender, obesity, anatomical factors, muscle weakness and joint damage (sports activities), which combine to increase anti-inflammatory markers and proteases that eventually mediate joint destruction. Unlike many other pain conditions where the underlying injury usually heals, arthrosis is a disease that usually does not resolve [2].

Solutions

Osteoarthritis is often managed with exercise, weight loss, physiotherapy, pharmacological interventions and surgery. However, less invasive strategies such as replenishment can also be considered. In a recent meta-analysis and systematic review, Liu and colleagues [3] pooled most of the studies looking at the effects of different dietary supplements for the treatment of osteoarthritis. This investigation included 69 studies and 20 supplements, which reported a small reduction in pain for studies that individually used glucosamine, chondroitin, methylsulfonylmethane and curcumin. Although the effect sizes are relatively small, the combination of these ingredients can potentially act synergistically to a greater extent improves joint pain. In addition, the same study showed that these supplements are safe when taken in the recommended amounts.

As a result, INN Supplements has developed its own formula based on current research ArthroID PRO which combines the above ingredients in the right quantities to offer a synergistic effect in a single product. This product is not actually intended to replace primary interventions such as physiotherapy, weight loss or surgery. However, it can alleviate acute joint pain, which is often reported in patients with osteoarthritis, and may offer a synergistic effect when combined with primary interventions.

Sources:

[1] Vina ER, Kwoh CK. Epidemiology of osteoarthritis: literature update. Curr Opin Rheumatol. 2018 Mar;30(2):160-167. doi: 10.1097/BOR.0000000000000479. PMID: 29227353; PMCID: PMC5832048.

[2] Grässel S, Muschter D. Recent advances in the treatment of osteoarthritis. F1000Res. 2020;9: F1000 Faculty Rev-325. Published 2020 May 4. doi:10.12688/f1000research.22115.1

[3] Liu X, Machado GC, Eyles JP, et al. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. British Journal of Sports Medicine 2018;52:167-175.